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Osteo-D 2000IU Chewable Tablet
Cholecalciferol (Vit. D3)
- Primary Uses:
- Osteoporosis
- Hypoparathyroidism
- Rickets
- Osteomalacia
- Vitamin D deficiency
- Pseudohypoparathyroidism
- Familial hypophosphatemia
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✅ Description:
Functions of Vitamin D3
Bone and Teeth Health:
- Facilitates calcium and phosphate absorption for strong bones and teeth.
- Prevents conditions like rickets, osteomalacia, and osteoporosis.
Pregnancy and Breastfeeding:
- Essential to prevent pre-eclampsia in pregnant women.
- Supports the growing infant's need for this vital nutrient during breastfeeding.
Immune System Support:
- Plays a critical role in boosting immunity, and reducing the risk of infections and immune-related disorders.
Deficiency Causes
- Common in individuals who spend extended time indoors or in areas with minimal sunlight.
- Lack of foods rich in vitamin D3 (e.g., fish, eggs, fortified foods).
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✔️ Dosage Guidelines
Adults:
Nutritional Deficiency:
- 200–400 IU/day (5–10 mcg).
Osteoporosis (Prophylaxis and Treatment, >50 years):
- 800–1000 IU/day (20–25 mcg) with calcium supplements.
Hypoparathyroidism:
- 50,000–200,000 IU/day (0.625–5 mg) with calcium supplements.
Children:
Nutritional Supplementation (RDA):
- 0–12 months: 400 IU/day (10 mcg).
- 1–18 years: 600 IU/day (15 mcg).
Vitamin D-Resistant Rickets:
- 12,000–500,000 IU/day (0.3–12.5 mg).
Familial Hypophosphatemia:
- 40,000–80,000 IU/day (1–2 mg) with phosphate supplements.
✔️ Administration
- Oral or IM: This may be taken with or without food.
✔️ Mechanism of Action
- Vitamin D3 helps regulate calcium and phosphate homeostasis for proper bone mineralization.
- Essential for calcium absorption in the gastrointestinal tract.
- Stimulates bone formation and promotes healthy bone structure.
✔️ Side Effects
- Hypercalcemia syndrome or calcium intoxication, symptoms may include:
- Anorexia
- Headache
- Dry mouth
- Nausea and vomiting
- Abdominal pain or constipation
✔️ Drug Interactions
- Increased Risk of Hypercalcemia:
- With thiazide diuretics, calcium, or phosphate supplements.
- Reduced Efficacy:
- With antiepileptics (carbamazepine, phenobarbitone, phenytoin), rifampicin, and isoniazid.
- Counteraction:
- By corticosteroids.
- Other Considerations:
- Reduced absorption when taken with cholestyramine, colestipol, mineral oil, or orlistat.
- Interaction with digoxin or cardiac glycosides.
- Ketoconazole may interfere.
✔️ Contraindications
- Diseases associated with hypercalcemia.
- Known hypersensitivity to cholecalciferol or any excipients.
- Evidence of vitamin D toxicity.
✔️ Precautions
- Caution advised in:
- High calcium or phosphate levels.
- Heart problems or kidney disease.
- Must be paired with adequate calcium and magnesium intake.
- Use with caution during lactation, as it is distributed in breast milk.
✔️ Key Benefits of Vitamin D3 Supplementation
- Enhances bone mineral density and reduces fracture risks.
- Supports muscle function and reduces fall risks in older adults.
- Aids fetal development and infant growth by ensuring optimal calcium levels.
- Contributes to a robust immune defense against infections and chronic diseases.
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lab tests, medicines, all possible side effects, drug interactions,
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